Updates in Antibody-Drug Conjugate Therapy for Breast Cancer: Focusing on TROP2-Directed Therapy

PROGRAM CHAIR

Aditya Bardia, MD, MPH, FASCO
Professor of Medicine
Geffen School of Medicine at UCLA
Director, Breast Oncology Program
Assistant Chief, Translational Research, Division of Medical Oncology
Director, Translational Research Integration
UCLA Health Jonsson Comprehensive Cancer Center
Los Angeles, CA

FACULTY PRESENTER

Reshma L. Mahtani, DO
Chief of Breast Medical Oncology
Baptist Health South Florida
Miami Cancer Institute
Miami, FL

PROGRAM OVERVIEW

This Grand Rounds program will help you understand the biology of TROP2 in breast cancer; examine the rationale for use of TROP2-directed antibody-drug conjugates (ADCs) in breast cancer; recognize adverse effects most commonly associated with ADCs and best practices for their prevention, mitigation, and management; and formulate strategies for integrating TROP2-directed ADCs into breast cancer treatment algorithms. This interactive program combines didactic instruction with case-based discussions and illustrative animations.

TARGET AUDIENCE

This educational activity is intended for community-based medical oncologists and other healthcare providers who care for patients with breast cancer.

LEARNING OBJECTIVES

Upon the completion of this program, attendees should be able to:

  • Describe the scientific rationale for use of TROP2-targeted antibody-drug conjugates in the management of breast cancer
  • Summarize updates of clinical trials informing development of TROP2-targeted antibody-drug conjugates in breast cancer
  • Evaluate potential adverse events associated with TROP2-targeted antibody-drug conjugates for advanced breast cancer

JOINT ACCREDITATION STATEMENT

In support of improving patient care, Med Learning Group is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


PHYSICIAN CREDIT DESIGNATION STATEMENT

Med Learning Group designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.

NURSES (ANCC) CREDIT DESIGNATION

Med Learning Group designates this activity for a maximum of 1.0 ANCC contact hour.

DISCLOSURE POLICY STATEMENT

In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.

DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS

 

Faculty Member  Disclosures
Aditya Bardia, MD Consulting Fee: Pfizer, Novartis, Genentech, Merck, Eli Lilly, Menarini, AstraZeneca, Daiichi Sankyo, Inc.

Contracted Research: Pfizer, Novartis, Genentech, Merck, Eli Lilly, Menarini, AstraZeneca, Daiichi Sankyo, Inc.

Reshma Mahtani, DO Consulting Fee: Agendia, AstraZeneca, Daiichi Sankyo, Inc., Eisai, Genentech, Gilead, Hologic, Lilly, Novartis, Pfizer, Puma, Sanofi, Stemline, Sermonix

All relevant financial relationships have been mitigated.

Content Review

The content of this activity was independently peer reviewed by a physician and nurse reviewer.

Individuals in Control of the Content of the Activity

The individuals in control of the content of this activity have reported the following financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CE activity:

  • Matthew Frese, MBA, General Manager of Med Learning Group, has nothing to disclose.
  • Christina Gallo, SVP, Educational Development for Med Learning Group, has nothing to disclose.
  • Michael Milano, MD, has received royalties from Wolters Kluwer (Up ToDate author royalties).
  • A medical reviewer from CME Peer Review LLC has nothing to disclose.
  • Shannon Mutch MS, RN, OCN, has nothing to disclose.
  • Kim Farina, PhD, Medical Director for Med Learning Group, has nothing to disclose.
  • Lauren Welch, MA, VP, Accreditation and Outcomes for Med Learning Group, has nothing to disclose.
  • Jessica McMullen, MPH, Senior Program Manager for Med Learning Group, has nothing to disclose.
  • Savannah Barron, Program Coordinator for Med Learning Group, has nothing to disclose.
  • Daniel DaSilva, Accreditation and Outcomes Coordinator, has nothing to disclose.

DISCLOSURE OF UNLABELED USE

Med Learning Group requires that faculty participating in any CE activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States. During this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.

METHOD OF PARTICIPATION

There are no fees for participating and receiving CE credit for this activity. In order to obtain your certificate for the mentioned accreditation, participants need to successfully complete the associated pre/post activities and evaluation. Your certificate will be provided as a downloadable file.

DISCLAIMER

Med Learning Group makes every effort to develop CE activities that are science based. This activity is designed for educational purposes. Participants have a responsibility to use this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making expertise before applying any information, whether provided here or by others, for any professional use.

For CE questions, please contact Med Learning Group at [email protected]

Contact this CE provider at Med Learning Group for privacy and confidentiality policy statement information at www.medlearninggroup.com/privacy-policy/

AMERICANS WITH DISABILITIES ACT

Event staff will be glad to assist you with any special needs (eg, physical, dietary, etc). Please contact Med Learning Group prior to participating at [email protected]

RELEASED DATE: October 30, 2024
EXPIRATION DATE: October 30, 2025

Copyright © 2024 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

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